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SFB 670 TP12: Molecular mechanisms of dendritic cell signal transduction subsequent to cellular infection by Vaccinia Virus or L. monocytogenes
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
This project aims at the characterization of cell-autonomous signal transduction in dendritic cells during infection with L. monocytogenes or vaccinia virus, respectively. The first part aims at the elucidation of the role of beta-2 integrins during phagocytosis. Our working hypothesis is that PRRmediated signals result in defined conformational changes in integrin molecules and that these structural alterations are required for pathogen uptake.
Dendritic cell maturation, the second subject of this project, is required for optimal antigen presentation and is normally controlled by PRRs. We hypothesize that important (e.g. Vav-1-dependent) maturation signals are coupled to the recruitment and modulation of the actin cytoskeleton by cytoplasmic intruders.
Section overview
Subjects
- Animal health
