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SFB 670 TP20: Distinction of self versus viral RNA by RIG-I and implication for viral infection
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
Specifically, the following questions will be answered:
a) What are the exact structural requirements for immunorecognition of 5´triphosphate RNA?
b) Is 5´triphosphate RNA the direct ligand for RIG-I?
c) How is the distinction of viral 5´triphosphate RNA from self RNA in cells accomplished?
d) Does detection of viral RNA by RIG-I require active viral replication?
e) How can an optimal antiviral immune response in vivo be achieved with 5´triphosphate RNA?
f) Can 5´triphosphate RNA be used to treat viral infections in vivo?
With the answers to these questions, the chapter on immunorecognition of RNA viruses may need to be rewritten, and new avenues of oligonucleotide-based therapeutics for treating viral infection may appear on the horizon.
Section overview
Subjects
- Biotechnology
