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Institute for Physiological Chemistry
Institution
Section overview
Description
Research at the Department of Physiological Chemistry links the pathophysiology of the intestinal mucosa with the cell biology of membrane and protein transport. Initial work has focused on the molecular basis of intestinal malabsorption disorders in genetically determined disaccharidases deficiencies, such as congenital sucrase-isomaltase deficiency and on the elucidation of structural-functional, biosynthetic and trafficking features of intestinal brush border membrane glycoproteins. Particularly mutant phenotypes of the affected proteins in malabsorption disorders have been crucial in discovering components and mechanisms of protein and membrane transport. Most notably, naturally-occurring mutants of sucrase-isomaltase provided significant clues on the location, nature and type of sorting signals in the early and late secretory pathways of membrane glycoproteins and proposed novel trafficking mechanisms.
Activities
- Research
Parent institution
Contact
Institute for Physiological Chemistry
Bünteweg 17
30559 Hannover
Lower Saxony
Germany
Phone: +49-511-953-8781
Fax: +49-511-953-8780
