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Detection of Clostridium botulinum and Clostridium botulinum Neurotoxin. Part of the research Project: Role of Clostridium botulinum in chronic disease
Project
Project code: FLI-IBIZ-08-Je-0091
Contract period: 01.02.2012
- 01.05.2014
Purpose of research: Experimental development
Relevance of Clostridium botulinum for the development of chronic unspecific clinical symptoms in dairy cattle - Detection of Clostridium botulinum and Clostridium botulinum Neurotoxin Within a cooperation project together with the “Tierärztliche Hochschule Hannover” (TiHo) the FLI will investigate faecal samples for the presence of C. botulinum neurotoxin (BoNT) via mouse-bioassay and for C. botulinum vegetative cells or spores. The aim of this investigation is to gain knowledge regarding the hypothesis of the so called visceral botulism. The principal point of this hypothesis is the detection of BoNT in the faeces of affected animals, which is so far not proven. Furthermore the faecal samples will be investigated by PCR and real-time PCR methods for the presence of C. botulinum vegetative cells or spores by the project partner TiHo and the FLI to collect information about the prevalence of the organism and to compare the different methods. The collection of samples and their assignment to an epidemiological category is realised by the TiHo.
Jensen KC, Frömke C, Schneider B, Do Duc P, Gundling F, Birnstiel K, Schönherr F, Scheu T, Kaiser-Wichern A, Woudstra S, Seyboldt C, Hoedemaker M, Campe A (2019) Case-control study on factors associated with a decreased milk yield and a depressed health status of dairy herds in northern Germany. BMC Vet Res 15(1):442. Jensen, K. C.; Frömke, C.; Schneider, B.; Sartison, D.; Duc, P. D.; Gundling, F.; Scheu, T.; Wichern, A.; Fohler, S.; Seyboldt, Christian GND; Hoedemaker, M.; Kreienbrock, L.; Campe, A (2017) Case-control study on chronic diseases in dairy herds in northern Germany: Symptoms at the herd Ievel. Berliner und Münchener tierärztliche Wochenschrift Vol. 130, H. 9/10S. 404-414 DOI:10.2376/0005-9366-16047 Fohler S, Klein G, Hoedemaker M, Scheu T, Seyboldt C, Campe A, Jensen KC, Abdulmawjood A (2016) Diversity of Clostridium perfringens toxin-genotypes from dairy farms. BMC Microbiol 16(1):199. doi: 10.1186/s12866-016-0812-6. Fohler S, Discher S, Jordan E, Seyboldt C, Klein G, Neubauer H, Hoedemaker M, Scheu T, Campe A, Charlotte Jensen K, Abdulmawjood A (2016) Detection of Clostridium botulinum neurotoxin genes (A-F) in dairy farms from Northern Germany using PCR: A case-control study. Anaerobe 39:97-104. doi: 10.1016/j.anaerobe.2016.03.008. Seyboldt C, Discher S, Jordan E, Neubauer H, Jensen KC, Campe A, Kreienbrock L, Scheu T, Wichern A, Gundling F, DoDuc P, Fohler S, Abdulmawjood A, Klein G, Hoedemaker M (2015) Occurrence of Clostridium botulinum neurotoxin in chronic disease of dairy cows. Vet Microbiol 177(3-4):398-402. doi: 10.1016/j.vetmic.2015.03.012.
Section overview
Subjects
- Animal health
Framework programme
Funding programme
Excutive institution
FLI - Institute for Bacterial Infections and Zoonoses (FLI-IBIZ)
