We use cookies on our website. Some are necessary for the operation of the website. You can also allow cookies for statistical purposes. You can adjust the data protection settings or agree to all cookies directly.
Data Protection Declaration
Imprint
Identification of new molecular proteomic biomarker for the risk assessment of food related compounds; heat-tox products as important example (furan fatty acids and 3-MCPD)
Project
Project code: BfR-LMS-08-1322-230
Contract period: 01.01.2006
- 31.12.2008
Purpose of research: Applied research
Furan fallty acids (FFA) are formed due to the heat treatment of unsatturated fatty acids but also are of natural origin in fish oils or some plants. BMELV announced at the last SKLM meeting in December 2007 that BfR has to make a principal risk assessment to this class of heat tox compounds. However, only few data to generate a full risk assessment are avail-able. The SKLM emphases the need of a risk assessment. According to the literature there are strong hints that the formation of the furan ring may induce serious toxic effects. We could show in our previous experiments to this project that FFA affects cell proliferation. However, their primary target organ is not the intestine but the liver and most likely endok-rine related organs. The CVUA in Stuttgart reported on the last SKLM meeting of other important heat tox com-pounds, the 3-MCPD ester. In margarine, butter and baby milk CVUA found incredible high levels of 3-MCPD ester. BMELV makes clear that BfR should comment this in the very next future. Due to the fact, that the available data to toxicity and exposition of this compounds are pure there is a great need for good data. Lipase are expressed in the human entero-cytes. Therefore, it is very likely that the 3-MCPD ester are cleaved in enterocytes and con-sequently enter the human body. Because of the high levels measured by CVUA this is a very scaring suggestion. The risk assessment has to address this questions. Therefore, this proposal will give quick answers to the questions. The result will be very important for the risk communication in regard to the risk 3-MCPD ester in baby milk.In further principle experiments using human models such as HepG2 cells, primary hepato-cytes and endocrine relevant target organ cells the epigenetic effects of furan fatty acid and 3-MCPD will be clarified. Furthermore, a proteomic approach will identify biomarker for the molecular effects of these heat-tox compounds.
Section overview
Subjects
- Biotechnology
- Toxicology
