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Imprint
Elucidating Pathomechanisms of Bacterial Viral Coinfections with New Biomedical Models (KoInfekt)
Project
Project code: FLI-ATB+IfI+IMVZ+IVD-08-HV-0039
Contract period: 01.01.2017
- 31.03.2021
Purpose of research: Applied research
Viral infections in the nasopharynx pave the way for subsequent bacterial infections, which can lead to severe courses of illness. In particular, coinfections of the so-called flu viruses - Influenza A viruses - with bacteria, which cause severe pneumonia, are connected to high annual mortality rates. KoInfekt plans to examine the coinfections of Influenza A viruses with the most important bacterial pathogens of secondary infections, Streptococcus pneumoniae, Streptococcus suis, Staphylococcus aureus and Streptococcus pyogenes. The goal is to elucidate the host-pathogen interactions, the course of illness and the host immune response in order to produce new strategies for fighting and preventing illness. These coinfections do not only occur in humans, but also in pigs. As there is an 80% match of the pig’s genome with the human’s genome, pigs are to be established as humanlike biomedical infection models for the coinfection of Influenza A Viruses with bacteria. KoInfekt’s results should establish improved prognoses for the course of illness of coinfections, as well as molecular biomarkers, and it is expected that the results will be translatable for use in clinical treatment.
Section overview
Subjects
- Animal health
- Biotechnology
Framework programme
Funding programme
Excutive institution
FLI - Department of Experimental Animal Facilities and Biorisk Management (FLI-ATB)
