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European Virus Archive goes global (EVAg)

Project

Risks

This project contributes to the research aim 'Risks'. Which funding institutions are active for this aim? What are the sub-aims? Take a look:
Risks


Project code: FLI-ATB-08-Ri-0382, 653316, 198648
Contract period: 01.04.2015 - 31.07.2020
Budget: 12,168,055 Euro
Purpose of research: Networks and research co-ordination
Keywords: virology

During the past century and especially the last decade with upcoming new technologies, a large number of pathogenic viruses with emerging potential have been discovered and isolated. These viruses are routinely used for basic research, epidemiological studies, disease control, development of diagnostics as well as for therapeutic purposes like the generation of novel vaccines and antivirals. Therefore, besides appropriate skills and capacities, the availability of suitable high quality reference material is crucial. ln 2009, a FP7 project called “European Virus Archive” (EVA) was conceived whereby the overall objective was to constitute a European network of high calibre centres with the appropriate expertise to identify, collect, amplify, characterise, standardise, authenticate, and distribute viruses. EVA has been operating satisfactorily and about 2000 products have been distributed worldwide. In order to continue and expand its activities the H2020 project “European Virus Archive goes Global” (EVAg; http://www.european-virus-archive.com/) has been founded by the European Commission, and consist of an international group of 25 laboratories. The ultimate goal of this non-profit organisation is to become the largest virus collection worldwide and provide eligible access to valuable high quality guaranteed viruses of all risk groups as well as virus-derived materials like viral genomes and proteins, suitable cell lines, antigen-specifi c sera or monoclonal antibodies, and to unique services including access to high biosafety level laboratories and animal facilities. Accordingly, EVAg is mainly involved in the development and distribution of diagnostic reference material e.g. during the emergence of viruses such as MERS-CoV or Zika virus.

As part of the EVAg project, the virtual database for existing viruses and derived products such as antibodies, proteins and cells could be greatly enlarged and the corresponding material was provided to external working groups for research purposes. The project funds were used at the FLI in particular for the complete sequencing of a large number of different interesting virus isolates. The information obtained can now be made available to interested working groups. In addition, other monoclonal antibodies to a wide variety of viral proteins were produced, which are also available for research purposes at other institutes. Romette et al. 2018 The European Virus Archive goes global: A growing resource for research. Antiviral Res. doi: 10.1016/j.antiviral.2018.07.017. Epub 2018 Jul 29.

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