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Imprint
Collaborative project: DNA markers for the breeding for resistance to pleuropneumonia in the pig – Subproject 2
Project
Project code: 28RZ372046
Contract period: 12.03.2015
- 28.02.2018
Budget: 558,507 Euro
Purpose of research: Applied research
This study deals with the identification of DNA markers, associated with resistance/susceptibility to porcine pleuropneumonia. These markers shall be used in selection to improve animal health, animal welfare, consumer safety and efficiency of pig production. DNA will be isolated in NGS quality from samples of pigs infected and accurately phenotyped by clinical, pathological and microbiological methods. Next generation sequencing will lead to a high marker density. After completion of phenotyping and sequencing of the most and least susceptible pigs, bioinformatics and association studies will be compiled. Association studies with phenotypical disease related traits will lead to the identification of the major gene variants involved in resistance to pleuropneumonia. Additionally, annotation and matching with functional, positional and regulatory data from previous studies may lead to a considerable improvement in the understanding of the mechanisms of disease and resistance. High throughput screening assays will be established for SNPs with the closest association to resistance traits to be tested under field conditions in a second approach.
Section overview
Subjects
- Animal health
