New research projects in FISA http://www.fisaonline.de/ Here you will find the latest 20 projects that have been included in the Information System for Agriculture and Food Research (FISA). en-en Federal Office for Agriculture and Food TYPO3 Collaborative project: Haplotype-based selection for climate-adapted elite winter wheat - subproject 6 The HaploSelekt project aims to identify genome-wide haplotype blocks and their phenotypic effects on yield performance under limited water and nutrient availability in elite wheat lines, and subsequently to develop computer-based crossing schemes to enrich beneficial haploblocks in resilient, high-performing breeding lines

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Collaborative project: Haplotype-based selection for climate-adapted elite winter wheat - subproject 5 The HaploSelekt project aims to identify genome-wide haplotype blocks and their phenotypic effects on yield performance under limited water and nutrient availability in elite wheat lines, and subsequently to develop computer-based crossing schemes to enrich beneficial haploblocks in resilient, high-performing breeding lines.

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Collaborative project: Haplotype-based selection for climate-adapted elite winter wheat - subproject 4 The HaploSelekt project aims to identify genome-wide haplotype blocks and their phenotypic effects on yield performance under limited water and nutrient availability in elite wheat lines, and subsequently to develop computer-based crossing schemes to enrich beneficial haploblocks in resilient, high-performing breeding lines.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13450&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=595851475fa2164236f75b92d861e0e5 Fri, 17 Jan 2020 10:36:54 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13450&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=595851475fa2164236f75b92d861e0e5
Collaborative project: Haplotype-based selection for climate-adapted elite winter wheat - subproject 3 The HaploSelekt project aims to identify genome-wide haplotype blocks and their phenotypic effects on yield performance under limited water and nutrient availability in elite wheat lines, and subsequently to develop computer-based crossing schemes to enrich beneficial haploblocks in resilient, high-performing breeding lines

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13449&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=09990851a6054f2a4476c24e41e838a5 Fri, 17 Jan 2020 10:33:41 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13449&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=09990851a6054f2a4476c24e41e838a5
Collaborative project: Haplotype-based selection for climate-adapted elite winter wheat - subproject 2 The HaploSelekt project aims to identify genome-wide haplotype blocks and their phenotypic effects on yield performance under limited water and nutrient availability in elite wheat lines, and subsequently to develop computer-based crossing schemes to enrich beneficial haploblocks in resilient, high-performing breeding lines.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13448&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=27e3e38e4bb8de972f83d7addfc4a5a7 Fri, 17 Jan 2020 10:31:13 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13448&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=27e3e38e4bb8de972f83d7addfc4a5a7
Collaborative project: Haplotype-based selection for climate-adapted elite winter wheat - subproject 1 The HaploSelekt project aims to identify genome-wide haplotype blocks and their phenotypic effects on yield performance under limited water and nutrient availability in elite wheat lines, and subsequently to develop computer-based crossing schemes to enrich beneficial haploblocks in resilient, high-performing breeding lines.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13447&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=6e4fa98025f5c6734cb65784b33beae9 Fri, 17 Jan 2020 10:28:23 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13447&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=6e4fa98025f5c6734cb65784b33beae9
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat - subproject 7 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13446&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=e02e5322035e0ef5b96cc7230b1d49cb Fri, 17 Jan 2020 10:19:30 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13446&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=e02e5322035e0ef5b96cc7230b1d49cb
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat - subproject 6 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13445&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=ff9421527237e8e318aac1df8a1f4c78 Fri, 17 Jan 2020 10:17:01 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13445&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=ff9421527237e8e318aac1df8a1f4c78
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat - subproject 5 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13444&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=6d0cf854264a68a0fd97085617b70023 Fri, 17 Jan 2020 10:13:49 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13444&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=6d0cf854264a68a0fd97085617b70023
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat - subproject 4 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13443&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=f2b420c5845eed45912aa2d5ed2a7988 Fri, 17 Jan 2020 10:10:42 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13443&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=f2b420c5845eed45912aa2d5ed2a7988
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat - subproject 3 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13442&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=3ac3052ce1d477b930c0ad4cee71fb46 Fri, 17 Jan 2020 10:00:39 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13442&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=3ac3052ce1d477b930c0ad4cee71fb46
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat - subproject 2 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13441&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=b1b4a07572d0a2cc5a9689e9da078e9d Fri, 17 Jan 2020 09:56:52 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13441&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=b1b4a07572d0a2cc5a9689e9da078e9d
Collaborative project: Investigation of the genetics of flowering biology in wheat for the effective production of hybrid wheat (HYFLOR) - subproject 1 Wheat hybrids use the heterosis effect in contrast to line varieties. On average, this increases grain yield by 10%, facilitates resistance breeding of genes with dominant effects and doubles yield stability. Despite these advantages, wheat hybrids have so far tended to have a niche existence with limited market penetrance. The main bottleneck lies in the high costs of hybrid seed production and the challenging selection of complementary parental lines. If dominance effects of genes for important agronomic traits are known, parents with complementary traits can be bred faster. The HYFLOR project therefore aims to create the basis for (1) improving pollination capability and receptivity as central characteristics of cost-effective hybrid seed production and (2) increasing knowledge-based the complementarity of genes underlying important agronomic traits. The project is divided into four work packages (WP). In WP 1, a reference data set for pollination capability in wheat is built up over extensive crossing blocks and phenotypic and genomic prediction models for pollination capability are developed. In WP 2, a reference data set for the receptivity of elite lines in wheat is created by carrying out crossing blocks in several environments and a phenotypic prediction model for receptivity is developed. In WP 3, we develop the quantitative genetic theory for North Carolina III designs based on multi-line crosses and map heterotic QTL in connected multi-line crosses evaluated in marginal environments. The aim is to estimate the degree of dominance of heterotic loci for important agronomic traits. These activities will be complemented by AP 4, in which the recurrent genomic selection program initiated within the ZUCHTWERT project will be completed in order to estimate the selection gain in field experiments.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13440&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=1a1fbd5efa93aad7dde034ee04a150ac Fri, 17 Jan 2020 09:53:06 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13440&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=1a1fbd5efa93aad7dde034ee04a150ac
Collaborative project: Development of target group-specific e-learning modules to improve animal welfare during transport and slaughter of cattle and pigs - subproject 2 European legislation to protect animals during transport (Reg. (EC) No. 1/2005) and slaughter (Reg. (EC) No. 1099/2009) explicitly requires training and documented expertise of the personnel involved. The objective of this project is to develop e-learning modules for truck drivers, slaughter plant personnel and veterinarians supervising transport and slaughter in order to improve animal welfare during transport and slaughter of cattle and pigs.After identification of the most relevant learning objectives, the different learning modules will be established in an E-Learning authoring tool using specifically generated video and text sequencies. Scientific findings on adult education in different target groups with different levels of socioeconomic background and nationality will be incorporated. Short interactive training sequences will induce an active engaged learning process in the participants. Short quizzes will allow self-reflection of the learning process. The close collaboration with an industry partner (Tönnies Holding AG) and the Faculty of Education, Freie Universität Berlin, as well as the use of a professional media development team will ensure that the developed tools are of high technical and educational quality. All e-learning modules will be freely accessible through a central project webserver and can be accessed through the internet via stationary and mobile devices. This ensures a wide distribution in the target population and establishes a similar level of training and therefore welfare standards among all stakeholders (such as truck drivers, abattoir personnel, veterinary authority personnel, veterinary and agricultural students, lecturers, welfare organizations etc.). Therefore it is to be expected that the developed tools, once they are widely used, will improve animal welfare standards in the respective processes and thus will result in a higher consumer acceptance.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13439&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=e6491277c8f42f8de93ee0c84637b91f Thu, 16 Jan 2020 10:46:18 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13439&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=e6491277c8f42f8de93ee0c84637b91f
Collaborative project: Development of target group-specific e-learning modules to improve animal welfare during transport and slaughter of cattle and pigs (eSchulTS2) - subproject 1 European legislation to protect animals during transport (Reg. (EC) No. 1/2005) and slaughter (Reg. (EC) No. 1099/2009) explicitly requires training and documented expertise of the personnel involved. The objective of this project is to develop e-learning modules for truck drivers, slaughter plant personnel and veterinarians supervising transport and slaughter in order to improve animal welfare during transport and slaughter of cattle and pigs.After identification of the most relevant learning objectives, the different learning modules will be established in an E-Learning authoring tool using specifically generated video and text sequencies. Scientific findings on adult education in different target groups with different levels of socioeconomic background and nationality will be incorporated. Short interactive training sequences will induce an active engaged learning process in the participants. Short quizzes will allow self-reflection of the learning process. The close collaboration with an industry partner (Tönnies Holding AG) and the Faculty of Education, Freie Universität Berlin, as well as the use of a professional media development team will ensure that the developed tools are of high technical and educational quality. All e-learning modules will be freely accessible through a central project webserver and can be accessed through the internet via stationary and mobile devices. This ensures a wide distribution in the target population and establishes a similar level of training and therefore welfare standards among all stakeholders (such as truck drivers, abattoir personnel, veterinary authority personnel, veterinary and agricultural students, lecturers, welfare organizations etc.). Therefore it is to be expected that the developed tools, once they are widely used, will improve animal welfare standards in the respective processes and thus will result in a higher consumer acceptance.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13438&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=b054e128fd4f9fe130247cd80d027647 Thu, 16 Jan 2020 10:41:45 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13438&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=b054e128fd4f9fe130247cd80d027647
Study on the key parameters for captive bolt stunning of cattle and further development of criteria for stunning effectiveness In the project, researchers of bsi Schwarzenbek cooperate with manufacturers of captive bolt guns and slaughterhouses. The objectives are to study the key parameters for animal welfare-friendly application of penetrating captive bolt stunning of cattle. Furthermore existing assessment schemes for stunning effectiveness shall be further elaborated. First of all a standardized assessment scheme will be used, to investigate the practice of captive bolt stunning in different slaughterhouses using different firing equipment (pneumatic / cartridge operated). Reactions after stunning are monitored and evaluated in relation to the selected key parameters. Further investigations will be performed on the best method for backup-stunning and to look after specific issues such as comparison of different bolt lengths, speeds and diameters. With the resulting description and standardization of the key parameters, the safety of captive bolt stunning will be increased. By visualizing the signs of good and bad stunning in graphics and short animations, communication in professional circles should be facilitated.

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Collaborative project: Method developments for the assessment of formulation impact on the activation of dendritic cells in coculture with keratinocytes - subproject 3 The aim of the present project is to investigate possible interactions between sensitizing fragrance molecules, other cosmetic ingredients as well as hair dye precursors for hair colorations commonly found in consumer products. This serves to improve the assessment of interactions between individual substances or of individual substances with matrices. The project will therefore identify factors that may complement and improve the current approaches for hazard and potency assessment. The endpoint for the assessment is the activation of dendritic cells in a skin-like environment (combination with keratinocytes), known to significantly influence the quality and intensity of antigen-specific T cell activation. This will be achieved by using different keratinocytes (HaCaT keratinocytes, pre-activated keratinocytes and epidermal skin models) in coculture with THP-1 cells as a model for dendritic cells. For example, fragrances, hair dyes and other cosmetic ingredients as well as individual formulations and mixtures thereof are added to cocultured cells or are applied to a skin model (epidermis model) with THP-1 cells placed on the basolateral side. In addition to the investigation of viability and activation state of the THP-1 cells, studies on changes in the release of cytokines and chemokines as well as on the fate or specific conversion of individual substances after exposure are carried out using mass spectrometric methods. The work will provide a test strategy tailored to answer the questions raised. Specifically, the results obtained for the materials tested will provide insights whether the potency of contact allergens can be influenced by other substances and, if so, whether this is specific to particular groups of chemicals. Overall, the results obtained will help a) to determine the extent of interactions, b) to perform their toxicological assessment and c) to consider consequences relevant for the safety assessment.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13436&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=c33e435c70af083558540de7ba1f5274 Thu, 16 Jan 2020 10:16:53 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13436&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=c33e435c70af083558540de7ba1f5274
Collaborative project: Method developments for the assessment of formulation impact on the activation of dendritic cells in coculture with keratinocytes - subproject 2 The aim of the present project is to investigate possible interactions between sensitizing fragrance molecules, other cosmetic ingredients as well as hair dye precursors for hair colorations commonly found in consumer products. This serves to improve the assessment of interactions between individual substances or of individual substances with matrices. The project will therefore identify factors that may complement and improve the current approaches for hazard and potency assessment. The endpoint for the assessment is the activation of dendritic cells in a skin-like environment (combination with keratinocytes), known to significantly influence the quality and intensity of antigen-specific T cell activation. This will be achieved by using different keratinocytes (HaCaT keratinocytes, pre-activated keratinocytes and epidermal skin models) in coculture with THP-1 cells as a model for dendritic cells. For example, fragrances, hair dyes and other cosmetic ingredients as well as individual formulations and mixtures thereof are added to cocultured cells or are applied to a skin model (epidermis model) with THP-1 cells placed on the basolateral side. In addition to the investigation of viability and activation state of the THP-1 cells, studies on changes in the release of cytokines and chemokines as well as on the fate or specific conversion of individual substances after exposure are carried out using mass spectrometric methods. The work will provide a test strategy tailored to answer the questions raised. Specifically, the results obtained for the materials tested will provide insights whether the potency of contact allergens can be influenced by other substances and, if so, whether this is specific to particular groups of chemicals. Overall, the results obtained will help a) to determine the extent of interactions, b) to perform their toxicological assessment and c) to consider consequences relevant for the safety assessment.

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https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13435&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=983abda684d02d215c3e5a56664a4258 Thu, 16 Jan 2020 10:13:55 +0000 https://fisa-typo38.prod.as.ble.de/en/find-projects/details/?tx_fisaresearch_projects%5Bp_id%5D=13435&tx_fisaresearch_projects%5Baction%5D=projectDetails&tx_fisaresearch_projects%5Bcontroller%5D=Projects&cHash=983abda684d02d215c3e5a56664a4258
Collaborative project: Method developments for the assessment of formulation impact on the activation of dendritic cells in coculture with keratinocytes - subproject 1 The aim of the present project is to investigate possible interactions between sensitizing fragrance molecules, other cosmetic ingredients as well as hair dye precursors for hair colorations commonly found in consumer products. This serves to improve the assessment of interactions between individual substances or of individual substances with matrices. The project will therefore identify factors that may complement and improve the current approaches for hazard and potency assessment. The endpoint for the assessment is the activation of dendritic cells in a skin-like environment (combination with keratinocytes), known to significantly influence the quality and intensity of antigen-specific T cell activation. This will be achieved by using different keratinocytes (HaCaT keratinocytes, pre-activated keratinocytes and epidermal skin models) in coculture with THP-1 cells as a model for dendritic cells. For example, fragrances, hair dyes and other cosmetic ingredients as well as individual formulations and mixtures thereof are added to cocultured cells or are applied to a skin model (epidermis model) with THP-1 cells placed on the basolateral side. In addition to the investigation of viability and activation state of the THP-1 cells, studies on changes in the release of cytokines and chemokines as well as on the fate or specific conversion of individual substances after exposure are carried out using mass spectrometric methods. The work will provide a test strategy tailored to answer the questions raised. Specifically, the results obtained for the materials tested will provide insights whether the potency of contact allergens can be influenced by other substances and, if so, whether this is specific to particular groups of chemicals. Overall, the results obtained will help a) to determine the extent of interactions, b) to perform their toxicological assessment and c) to consider consequences relevant for the safety assessment.

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Collaborative project: Development and validation of a cellular test system for allergen trace amount detection and determination of allergenic potential of processed foods - subproject 4 It is of utmost importance for consumers as well as for food manufacturers that the allergen content of a product is correctly labeled. Allergic consumers need to be certain that a safe product is consumed and manufacturers want to avoid unnecessary labeling. Ideally only food products truely implying a certain risk for affected persons should be labeled, improving the freedom of choice via optimized consumer information and increasing the number of potential consumers/customers numbers for a certain product. Detection of allergens in compound food products is possible in a qualitative manner via rapid test systems as well as quantitatively in the laboratory using ELISA (enzyme linked immunosorbent assay), PCR (polymerase chain reaction) or mass spectrometry. Sensitivity and specificity of such tests depend on the target allergen, the food matrix as well as on processing of the food. However, results of these test systems will only answer the question whether and how much of an allergen or allergenic ingredient is present in the food analyzed. The allergenic potential of a food – a measure of the probability for an allergic reaction in susceptible consumers – cannot be determined in this manner. Thus this joint research project aims at establishing a cell-based test system that allows for determination of the allergenic potential of processed food. The test system is based on a humanized rat basophil cell line that was generated and validated for use in standardization of allergen products by the applicants. There is no need for animal experiments. Peanut and hazelnut were chosen as example allergen sources.

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