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Relevancy: 100%
Potential influence of methylisothiazolinone on processes of antigen presentation and inflammation (Project)
According to the current understanding of human contact allergy (type IV), chemicals such as MI (=MIT, methylisothiazolinone) or MI/MCI (MI/methylchloroisothiazolinone) - which are also frequently used as preservatives in cosmetics - bind as haptens to proteins (self-proteins) or peptides and form so-called T-cell epitopes, which can trigger an MI allergy. These are not known for MI. At the same...
Funding period: 2020 - 2023
Relevancy: 100%
Individual allergy diagnostics for putative pigment allergy within tattoos (Project)
About one third of non-infectious intolerance reactions to tattoo ink have an allergic pathogenesis. Up to now, no commercially available test allergens are available for the identification of skin-sensitizing pigments by patch testing.The proposed project will make tattoo pigments in small quantities available to treating physicians in the IVDK network for the preparation of test allergens...
Funding period: 2023 - 2026
Relevancy: 100%
Development of analytical methods for the characterization of the emissions of volatile and semi-volatile substances from consumer products (Project)
People living in industrialized nations spend the majority of their time in indoor environments, thus the quality of indoor air plays an increasing important role for the human health. Volatile organic compounds (VOCs) are one group of substances, which pollute the indoor air. They can be emitted from construction products, furnishing and other consumer products, such as toys, clothing and...
Funding period: 2021 - 2023
Relevancy: 100%
Development of qualitative, quantitatve and imaging analytical methods for the analysis of tattoo inks, pigments, particles, fibres and consumer products (research focus 3, department 7) (Project)
Different topics relevant to the BfR in the field of non-food-products require the use of specialized test procedures or the development of analytical methods to accurately describe materials and consumer products. Such newly developed methods can be relevant in the context market surveillance, hazard and risk assessment or research in many areas. This includes the investigation, identification...
Funding period: 2025 - 2025
Relevancy: 100%
Kinetics of short-chain and alternative PFAS in humans (Project)
The ubiquitous contamination of the environment and food chain with per- and polyfluorinated alkyl substances (PFAS) has led to internal human exposure, which can be detected in everyone's blood. The focus here is on the so-called long-chain compounds (C8 and more for carboxylic acids, C6 and more for sulfonic acids) because they have extremely long half-lives in humans, in the range of years....
Funding period: 2024 - 2025
Relevancy: 100%
Development of novel application methods and evaluation strategies for the genotoxic and phototoxic assessment of tattoo pigments and poorly soluble substances in in vitro assays (Project)
A number of substance classes exhibit extremely low solubility in aqueous media due to molecule-specific properties and predominantly occur in micro- and nanoparticulate forms. Due to their strong tendency to aggregate, the interaction of these substances with the biochemical cellular apparatus is significantly reduced when considering their chemical single-molecule characteristics. However,...
Funding period: 2025 - 2025
Relevancy: 100%
Comparative investigations of different in vitro methods for the applicability to the detection of the sensitizing potential of pigment particles and tattoo ink allergens (Project)
The BfR has been active in the field of allergy and tattoo ink research since 2012 to better understand the hazard potential of this intradermal color application and to provide a better basis for risk assessment. In this project, testing of tattoo-relevant substances and color particles will be performed using validated OECD methods and the in-house developed AIM T cell assay to test for...
Funding period: 2023 - 2025
Relevancy: 100%
Development of analytical method for identification and quantification of tattoo pigments and inks (Project)
Although tattoo pigments are generally substances of low solubility, detailed investigations of their solubility under physiological condition are needed. Besides dissolved pigment material, releases from the pigments can include contaminations, degradation products – especially from UV-/light-radiation – or metabolites. Within this project, tattoo inks and the respective tattoo pigments will...
Funding period: 2024 - 2027
Relevancy: 100%
Enhanced Life-Cycle-Costing in wood construction by novel methods for service life planning (Project)
Enhanced Life-Cycle-Costing in wood construction by novel methods for service life
Funding period: 2023 - 2025
Relevancy: 100%
Cultivation of Gambierdiscus for the extraction of ciguatoxins (CTX) (Project)
Ciguatoxins (CTXs) are a group of marine biotoxins. CTXs are complex lipophilic polyethers, produced by dinoflagellates. Because of their lipophilic properties, CTXs can accumulate in the marine food web after being consumed and subsequently can undergo biotransformation processes. To date, over 30 different CTX congeners have been described. These congeners can be detected in various marine...
Funding period: 2023 - 2024
