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FLI - Institute of Molecular Pathogenesis (FLI-IMP)
Institution
Section overview
Description
In the Institute of Molecular Pathogenesis (IMP), the main topics of research and official tasks include infections caused by Mycobacteria spp. and Chlamydiaceae spp. The following National Reference Laboratories (NRLs) are located in the IMP: NRL tuberculosis, NRL paratuberculosis, NRL psittacosis, and NRL dourine. All NRLs fulfil official tasks including the surveillance and improvement of diagnostic methods for notifiable animal diseases and zoonoses at a national and international level.
Activities
- Research
Parent institution
Friedrich-Loeffler-Institute - Federal Research Institute for Animal Health (FLI)
Coordinated projects
- D2.5 Key factors determining intensity of shedding of M. bovis and C. burnetii from animal reservoir species
- D4.1 Distribution data on the O104:H4 serotype in animal reservoirs
- Development of novel DNA microarray-based tests for rapid detection and genotyping of chlamydiae
- Differentiation of Mycobacterium avium subsp. paratuberculosis isolates – Relation between genotype and phenotype
- Differentiation of Mycobacterium avium subsp. paratuberculosis isolates of different origin by a new standardised typing protocol
- Enhanced control of CBPP in sub Saharan Africa through development of better diagnostics and vaccines
- Generation and characterization of 3D-organoids from bovine colon material to investigate the interactions of zoonotic bacteria with the host mucosa. Subproject: Obtaining and characterizing bovine intestinal three-dimensional cell culture systems
- Improved diagnosis and control of bovine mycoplasmosis
- In vitro replication of Trypanosoma euiperdum for production of antigen for dourine diagnosis
- o D9.1 Defined comparative pro-inflammatory and immunomodulating capacity of stx+EAEC O104:H4
- One Health AMR Surveillance through Innovative Sampling
- Recombinant E. coli Shiga toxoids as broadly cross-protective vaccines to reduce STEC/EHEC shedding and transmission dynamics in cattle herds
- The reservoir within the reservoir: geno- and phenotypic characteristics of STEC strains persistently colonizing cattle
- Trans-sectoral transfergroup antiinfectiva
- Vaccination as a tool to reduce the incidence of paratuberculosis in dairy goat flocks
Work package leader of collaborative projects
Involved in research projects
- Epidemiology, prophylaxis and control of Salmonella infections in farm animals and other animal species
- HealthyGut - Multi-focal strategies to improve gut health and reduce enteritis in poultry and pigs
- Identification of host-derived biomarkers of latent infections with Mycobacterium avium ssp. paratuberculosis (MAP)
- Improvements in the diagnosis and control of bovine mycoplasmosis
- Integrated control of neglected zoonoses: improving human health and animal production through scientific innovation and public engagement (ICONZ)
- Novel technologies for surveillance of emerging and re-emerging infections of wildlife (WILDTECH)
- PET / CT for imaging of infection and inflammation: reduction, refinement and replacement of animal experiments
- Salmonella-free broilers by live-vaccine-induced innate resistance to colonisation and invasion and novel methods to eleminate vaccine and field strains
Contact
FLI - Institute of Molecular Pathogenesis
(FLI-IMP)
Naumburger Straße 96a
07743 Jena
Thuringia
Germany
Phone: +49 3641 804-2478
Fax: +49 3641 804-2482
Email: Sabine.Lenk(@)fli.bund.de