We use cookies on our website. Some are necessary for the operation of the website. You can also allow cookies for statistical purposes. You can adjust the data protection settings or agree to all cookies directly.
Investigation of mixture effects of pesticides in vitro (Combiomics 2)
Project
Project code: BfR-LMS-08-1334-229
Contract period: 01.01.2017
- 31.12.2019
Purpose of research: Applied research
Consumers are exposed to residues of various pesticides via foodstuff. Due to the fact that the toxicological properties of pesticidal active substances are mostly assessed on a single-compound basis in animal experiments for regulatory purposes, data on possible combination effects are scarce. The investigation of combination effects, which is foreseen by the respective guidelines for evaluation and authorization of pesticidal active substances, thus poses a challenge to regulatory toxicology. The development of in vitro systems for the assessment of combination effects is of utmost importance, since the multitude of investigations cannot be performed in animals. During the first project phase combination effects of a group of fungicides (triazoles) were investigated. Several cell lines were screened for their suitability to analyze mixture effects using omics techniques. In the second phase of the project, successfully tested methods and cell lines will be validated in a standardized in vitro testing battery aimed to comply with future regulatory requirements.
Section overview
Subjects
- Crop Protection
- Toxicology