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Specific and sensitive marker diagnostics: Development of a DIVA diagnostic
Project
Project code: 2813101606
Contract period: 01.01.2007
- 31.12.2009
Budget: 375,482 Euro
Purpose of research: Experimental development
In addition to the marker vaccine itself, the ability to detect serological reactions of the vaccinee by means of the marker principle is required for the implementation of a DIVA (differentiating infected from vaccinated animals) vaccination concept. With regard to vaccination against fowl plague, three strategies are possible, however, the large species spectrum makes it a difficult task. The difficulty increases when the additional vaccination of zoo birds is considered. Therefore, test types which are based on the competitive ELISA principle and thus permit a species-independent antibody detection will be focussed on. A prerequisite for the establishment of such tests is the production of immunogenic recombinant proteins and the production of competitive monoclonal antibodies against these target antigens. In the laborious validation stage, highly specific and well documented reference sera and an adequate statistical support as well as tests under field conditions are required.
Section overview
Subjects
- Animal health
- Biotechnology
