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Data Protection Declaration
Imprint
Influence of formulation parameters on absorption of pesticides across the skin
Project
Project code: BfR-SiP-08-1322-684
Contract period: 01.01.2017
- 31.01.2018
Purpose of research: Applied research
The estimation of dermal absorption represents a crucial step in human risk assessment of plant protection products and biocidal products for operators as well as by-standers. The extent of dermal absorption can have a major impact on authorisation decisions and risk mitigation measures. Testing of dermal exposure of pesticides is performed according to OECD TG 427 and TG 428 and depends on the experimental exposure settings as well as the formulation tested. Therefore, the collected data relates to a specific formulation and typical exposure conditions. In regulatory risk assessment such data usually needs to be extrapolated to different formulations and exposure conditions. Practical but conservative guidance is provided by EFSA (EFSA Guidance on Dermal Absorption, 2012) and OECD (OECD GN 156, 2011). Further knowledge concerning the influence of exposure conditions and formulation parameters is needed to meet current challenges in regulatory risk assessment. Furthermore, there is a focus on the reduction of animal testing, which can be achieved by the use of in vitro as well as in silico methods. Currently, in silico methods are only partially accepted in risk assessment. To improve the acceptance and further use of in silico methods in the field of dermal absorption, refinement of these methods should be proposed. A crucial step, therefore, is the identification of relevant parameters affecting the biological process and to propose parameters improving the computational models. It is planned to refine the methodology for the estimation of the extent of absorption of active substances across the skin, based on the exsisting BfR database 'Dermale Absorption'. Moreover, formulation parameter should be integrated in the database and correlated to the dermal absorption values. This project aims to improve the risk assessment of active substances in different formulations in the field of pesticides.
Section overview
Subjects
- Crop Protection
- Toxicology
