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Imprint
SFB 670 TP11: Antiviral defence mechanisms in liver sinusoidal endothelial cells
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
Liver sinusoidal endothelial cells (LSEC) take up viruses from the bloodstream, but are not productively infected by these viruses. We plan to characterize the molecular mechanisms in LSEC, which are involved in recognition of the model DNA virus MCMV. Moreover, we will investigate, which signal pathways are involved in induction of type I interferon, inhibition of viral replication and increase in costimulation in MCMV-infected LSEC in comparison with dendritic cells. Using endothelial cell-type specific conditional knockout mice we will characterize the relevance of selected signal pathways in endothelial cells for MCMV infection in vivo.
Section overview
Subjects
- Animal health
Collaborative Project
Funding programme
Excutive institution
Institutes of Molecular Medicine and Experimental Immunology (IMMEI)
