We use cookies on our website. Some are necessary for the operation of the website. You can also allow cookies for statistical purposes. You can adjust the data protection settings or agree to all cookies directly.
Data Protection Declaration
Imprint
Analysis of effects from trans-fatty acids on miRNA expression profiles of human colon cells
Project
Project code: BfR-LMS-08-1322-474
Contract period: 01.03.2011
- 31.12.2011
Purpose of research: Applied research
Trans-fatty acids (TFA) are generated during industrial oil hardening and refinement processesat high temperatures and have diverse adverse health effects. While there is a clearcorrelation between the consumption of TFAs and an increased risk for coronary heart diseases,a potential cancer risk is still controversially discussed.Small non-coding RNAs, microRNAs (miRNAs), are involved in carcinogenic processes. Byregulating target mRNAs they can act as oncogenes or tumorsupressors and it is known thatthey are differentially expressed in a multitude of tumors. Therefore the analysis of effectsfrom TFAs on the miRNA expression profile can be used to elucidate a potential cancerassociated risk of these food components.
Section overview
Subjects
- Physiology of Nutrition
