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Incidence and Characterization of Antibiotic Resistance Determinants in Salmonella Enteritidis Isolates from food and food-producing animals
Project
Project code: BfR-BIOS-02-L 501-05
Contract period: 01.05.2004
- 31.12.2005
Purpose of research: Basic research
Today Salmonella (S.) Enteritidis is the most common Salmonella enterica serovar isolated from humans worldwide and the most important cause of human outbreaks in Germany, too. The main reservoir of salmonellosis are domestic animals, particularly poultry, and wild life. Transmission results from the ingestion of contaminated foods of animal origin, such as poultry, eggs, milk, beef and pork. Unlike other dominating S. enterica serovars, like S. Typhimurium, S. Infantis, S. Derby, S. Hadar most of the S. Enteritidis isolates revealed no or only little antibiotic resistance in the past. However, in the last few years an increasing number of resistance determinants has been found and, in fact, genetic structures that mediate multidrug resistance has been detected by molecularbiological methods. Thus, it is to be expected that the number of resistance determinants will increase, if the pressure of selection will continue. The overall objective of this project is to provide data regarding the incidence and development of antibiotic resistance determinants in Salmonella Enteritidis isolates from food and food-producing animals. An additional objective is the molecularbiological characterization of the encoding antibiotic resistance genes and of the genetic structures (plasmids, integrons, transposons) mediating transmission and spread of resistance. Provided data are the basic for a risk analysis and for measures of risk management and, thus, contribute to the improvement of the health protection of consumers.
Section overview
Subjects
- Physiology of Nutrition
- Biotechnology
