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FLI - Institute of Diagnostic Virology (FLI - IVD)
Institution
Section overview
Description
The Institute of Diagnostic Virology studies economically important virus diseases of animals, mainly in terms of diagnosis and differential diagnosis. Special attention is given to notifiable diseases. National reference laboratories for classical swine fever, avian influenza, Newcastle disease, bovine herpesvirus 1-infection, infectious equine anemia, porcine encephalomyelitis, foot and mouth disease, swine vesicular disease, vesicular stomatitis and African swine fever, for bovine viral diarrhoe/mucosal disease as well as for exotic virus diseases of animals such as orbivirus infections or cattle plaque, are part of the institute and have been accredited officially according to ISO/IEC 17025. They conduct applied research and have official duties according to national and European legislation. The laboratories for avian influenza, Newcastle disease and BHV-1 were also confirmed as reference laboratories of the OIE. Furthermore, diagnostic procedures are being developed, improved and evaluated. Commercially available diagnostics are officially tested for licensing, and reagents which are not available commercially are developed and supplied to regional laboratories. In addition, research concerning the prophylaxis and pathogenesis of selected notifiable animal diseases is conducted. The laboratory in charge of the virus collection established at the institute focuses on collection, characterisation, maintenance and delivery of authentic virus strains and appropriate antisera. In addition, the generation of monoclonal antibodies used both within the Friedrich-Loeffler-Institut and in other diagnostic laboratories is one of the tasks of the institute.
Activities
- Research
Parent institution
Friedrich-Loeffler-Institute - Federal Research Institute for Animal Health (FLI)
Coordinated projects
- Bat influenza virus chimeras as basis for the development of a new type of vaccine backbone for live stock vaccination
- Collaborative Management Platform for detection and Analyses of (Re-)emerging and foodborne outbreaks in Europe
- Collaborative project: Emergency strategies against viral pathogens - subproject: Response to animal diseases and bioterrorism.
- Collaborative project: Incidence and impact of potentially disease associated viral DNA in cattle - subproject 2
- Detection of (avian) influenza A viruses in environmental samples
- Development of attenuated marker vaccines against classical swine fever (CSF) and bovine diarrhea / mucosal disease (BVD / MD)
- Diagnosis and control of Rabbit Haemorrhagic Disease (RHD)
- Entry and reassortment potential of the newly discovered bat influenza A-like viruses
- Epi-SEQ – Molecular epidemiology of epizootic diseases using next generation sequencing technology
- Experimental TBEV infection of bank voles (Myodes glareolus) (TBENAGER II)
- Improvement of next-generation sequencing methods for the detection of zoonotic pathogens
- Improving the understanding of the epidemiology of sheep and goat plague (Peste des petits ruminants, PPR)
- Investigations on the molecular epidemiology in the wild bird population
- Investigations on the susceptibility of selected bird species and mammals for the HPAIV H5N1 isolated in Germany
- Isolation and characterization of avian influenza H9N2 from mixed respiratory infected chickens in Bangladesh and assessment of mucosal immunization possibilities (AvH-Fellow)
- Modern molecular diagnostic methods: Development and use of the DNA chip technology for comprehensive influenza virus diagnostics
- Modern molecular diagnostic methods: ultrarapid ad hoc pathotyping and characterisation of AIV complete genomes
- Molecular biology and spill-over potential of bat influenza A-like viruses (Bat Influenza - 2. Funding Period)
- Monitoring with indicator animals in regions with a high water bird density
- National reference laboratory for Schmallenbergvirus infections
- Optimisation of conventional AIV diagnostics: AIV detection: sensitive recombinant cell culture systems
- Optimisation of the conventional AIV diagnostic: AIV detection: biochip detection, HI test, antigen rapid test
- Out of the reservoir: identification and characterization of viral and host factors governing the pathobiology of zoonotic cowpox viruses
- Phylogenetic analyses of Avian Influenzaviruses from wild birds in Ukraine and their connection to Isolates in Europe in the period 2010-2020. - Scientific Exchange
- Pilot study on the use of commercially available AIV H5 vaccines
- Rapid molecular detection of important transboundary viral animal diseases
- Reference materials for validation and quality assurance of avian influenza diagnostics
- Rindergrippe: Detection and characterization of viral pathogens of the bovine respiratory disease complex
- Serological investigations on the susceptibility of selected bird species and mammals in natural outbreak areas of the avian influenza H5N1 infection
- Specific and sensitive marker diagnostics: Development of a DIVA diagnostic
- Specific and sensitive marker diagnostics: Generation of monoclonal antibodies for serological diagnostic
- Suitability of milk serology for BVD monitoring
- Suitability of milk serology for BVD monitoring - 2
Coordinated collaborative projects
Work package leader of collaborative projects
Involved in research projects
- Development of a subunit and inactivated whole virus vaccine for immunisation of cats against an influenza H5N1 infection
- Development of scientifically based infection control guidelines in case of reintroduction of BHV-1 into cattle farms in North Rhine-Westphalia
- Development, enhancement and complementation of animal-sparing, foot-and-mouth disease vaccine-based control strategies for free and endemic regions (FMD-DISCONVAC)
- Elucidating Pathomechanisms of Bacterial Viral Coinfections with New Biomedical Models
- EMPERIE - European management platform for emerging and re-emerging infectious disease entities
- Epidemiology and control of rabies infections (National and OIE Reference Laboratory (Office International des Epizooties - World Organisation for Animal Health))
- EPIZONE - Network on epizootic disease diagnosis and control
- ESNIP 3 - European Surveillance Network for Influenza in Pigs 3
- Improve tools and strategies for the prevention and control of classical swine fever (CSFV_GoDIVA)
- Investigations on the pathogenesis of the haemorrhagic syndrome and on the organ tropism of highly virulent H5N1 isolates in different species
- NEW-FLUBIRD - Network for early warning of influenza viruses in migratory birds in Europe
- OrbiNet – Molecular and reverse genetics studies of orbivirus transmission, host responses, epidemiology and diagnostic systems
- ORBIVAC - Development of Vaccines for bTV, EHDV and AHSV
- RAPIDIA-FIELD - Rapid Field Diagnostics and Screening in Veterinary Medicine
- SUPASALVAC Salmonella-free broilers by live vaccine-induced innate resistance to colonisation and invasion and novel methods to eliminate vaccine and field strains
- Ticks and tick-borne diseases, investigations about biology of ticks and tick-borne diseases using the epidemiological example of Tick-borne-encephalitis-virus-(TBEV) infection
- Towards rational design of vaccines against African swine fever in East- and Southern Africa: Correlation of viral genome differences with their impact virulence and by analysis of viral and target cell transcription and protein expression.
- Zoonoses Anticipation and Preparedness Initiative
Contact
FLI - Institute of Diagnostic Virology
(FLI - IVD)
Südufer 10
17493 Greifswald - Insel Riems
Mecklenburg-Vorpommern
Germany
Phone: +49 38351 7-200
Fax: +49 38351 7-151
Email: martin.beer(@)fli.bund.de
