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Development of a single cell model of adult cardiomyocytes as a replacement method of animal experiments? Optical measurements of excitation-contraction coupling under the influence of test substances
Project
Project code: BfR-ZEBET-08-1328-205
Contract period: 01.08.2007
- 31.07.2009
Purpose of research: Applied research
The aim of the project is to find a parameter as an indicator for the influence of test substances on cardiac function by calcium measurements in isolated cultured cardiomyocytes. Compared to other techniques, this should provide a meaningful method according to the guidelines for drug safety. At the same time this method has the potential to replace and reduce animal experiments.
Section overview
Subjects
- Biotechnology
Framework programme
Funding programme
Excutive institution
BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET)